PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR
Identifieur interne : 002C42 ( Main/Exploration ); précédent : 002C41; suivant : 002C43PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR
Auteurs : Henning Pakkenberg [Suède] ; Erik Birket-Smith [Suède] ; Erik Dupont [Suède] ; Erie Hansen [Suède] ; Bent Mikkelsen [Suède] ; Jan Presthus [Suède] ; Ilkka Rautakorpi [Suède] ; Eva Riman [Suède] ; Urpo K. Rinne [Suède]Source :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 1976-06.
Abstract
92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.
Url:
DOI: 10.1111/j.1600-0404.1976.tb04355.x
Affiliations:
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Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Pakkenberg, Henning" sort="Pakkenberg, Henning" uniqKey="Pakkenberg H" first="Henning" last="Pakkenberg">Henning Pakkenberg</name></noRegion><name sortKey="Birket Mith, Erik" sort="Birket Mith, Erik" uniqKey="Birket Mith E" first="Erik" last="Birket-Smith">Erik Birket-Smith</name><name sortKey="Dupont, Erik" sort="Dupont, Erik" uniqKey="Dupont E" first="Erik" last="Dupont">Erik Dupont</name><name sortKey="Hansen, Erie" sort="Hansen, Erie" uniqKey="Hansen E" first="Erie" last="Hansen">Erie Hansen</name><name sortKey="Mikkelsen, Bent" sort="Mikkelsen, Bent" uniqKey="Mikkelsen B" first="Bent" last="Mikkelsen">Bent Mikkelsen</name><name sortKey="Presthus, Jan" sort="Presthus, Jan" uniqKey="Presthus J" first="Jan" last="Presthus">Jan Presthus</name><name sortKey="Rautakorpi, Ilkka" sort="Rautakorpi, Ilkka" uniqKey="Rautakorpi I" first="Ilkka" last="Rautakorpi">Ilkka Rautakorpi</name><name sortKey="Riman, Eva" sort="Riman, Eva" uniqKey="Riman E" first="Eva" last="Riman">Eva Riman</name><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. 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